TB-500 (Fequesetide / Ac-LKKTETQ) is a synthetic fragment of the naturally occurring 43-amino acid peptide Thymosin Beta-4 (Tβ4). While Tβ4 is found in high concentrations in platelets and wound fluid, TB-500 isolates the specific actin-binding domain (LKKTETQ). In 2026 research, this fragment is utilised to study the mobilization of progenitor cells and the regulation of the cellular cytoskeleton fundamental processes in tissue regeneration and angiogenic signaling.
Molecular Mechanisms of Interest
Actin Upregulation: TB-500 stimulates the production of actin, a vital structural protein that allows for cellular movement and support. Supporting literature: Actin and cytoskeletal dynamics PubMed
Cellular Migration: By binding to actin, the peptide facilitates the migration of cells to areas of experimental interest critical for studying dermal and corneal in-vitro repair. Supporting literature: Thymosin Beta-4 and cell migration PubMed
Angiogenesis Research: Studies explore TB-500’s role in promoting endothelial cell differentiation and the formation of new vascular networks. Supporting literature: Endothelial cell differentiation and angiogenesis PubMed
Dermal and Connective Tissue Analysis: Research focuses on the peptide’s influence on collagen deposition and downregulation of pro-inflammatory cytokines including IL-6. Supporting literature: Collagen deposition and IL-6 modulation PubMed
Technical Specifications
Fragment: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (TB-500) Molar Mass: 889.0 Da Purity (HPLC): ≥99.0% Appearance: White Lyophilised Powder Storage: -20°C long-term
Research Applications
TB-500 is actively utilised in laboratory research examining cytoskeletal architecture, progenitor cell mobilization, and vascular network formation. It is frequently studied alongside BPC-157 in synergistic tissue repair and angiogenic research protocols.
Supporting literature: Thymosin Beta-4 in tissue repair PubMed TB-500 and vascular network formation PubMed Progenitor cell mobilization PubMed
Our Recommended UK Supplier
TB-500 is available from Peptronic Labs UK-based, ≥99.0% purity verified by HPLC, Royal Mail Tracked 24. View TB-500 5MG
Important Notice: All content on this page is for laboratory research and educational purposes only. Not intended as medical advice or for human consumption.