CJC-1295 No DAC (Mod GRF 1-29) is a modified 29-amino acid peptide analog of Growth Hormone-Releasing Hormone (GHRH). In contrast to extended-release analogs, the No DAC variant is engineered to provide a high-affinity, short-duration signal to the pituitary gland. This allows researchers to study pulsatile secretion of growth hormone, closely mirroring endogenous biological rhythms.
Molecular Design
The No DAC variant is a tetra-substituted analog of the natural GHRH (1-29) sequence. Specific substitutions at positions 2, 8, 15, and 27 are designed to prevent enzymatic cleavage by DPP-IV, increasing laboratory stability compared to unmodified GHRH.
Sequence: [D-Ala2, Gln8, Ala15, Leu27]-GHRH (1-29) Half-Life: Approximately 30 minutes — designed for acute signaling studies Binding Profile: Selective agonist for GHRH receptors without albumin-binding complex
Supporting literature: GHRH receptor agonism and pulsatile GH secretion PubMed
Technical Specifications
CAS Number: 86168-78-7 Molecular Weight: 3367.9 g/mol Purity: ≥98.5% Solubility: Highly soluble in dH2O Formulation: Lyophilised (Freeze-Dried) Storage: -20°C long-term
Research Applications
CJC-1295 No DAC remains a gold standard for studying the GH/IGF-1 Axis due to its rapid clearance and lack of systemic accumulation. Core research applications include pulsatile GH signaling studies, metabolic substrate partitioning, and tissue repair modeling. It is frequently studied alongside Ipamorelin for dual-pathway secretagogue research.
Supporting literature: GH/IGF-1 axis and metabolic signaling PubMed Pulsatile growth hormone secretion PubMed GHRH analogs and tissue repair PubMed DPP-IV enzymatic cleavage resistance PubMed
Frequently Asked Questions
What is CJC-1295 No DAC used for in research? CJC-1295 No DAC is used in laboratory models to study pulsatile growth hormone secretion, the GH/IGF-1 axis, and metabolic signaling pathways.
How should CJC-1295 No DAC be stored? Store lyophilised powder at -20°C. Avoid rapid temperature fluctuations as this sequence is sensitive to heat-induced denaturing.
What is the purity of Peptronic Labs CJC-1295 No DAC? Peptronic Labs supplies CJC-1295 No DAC at ≥98.5% purity verified by Reversed-Phase HPLC.
Our Recommended UK Supplier
CJC-1295 No DAC is available from Peptronic Labs UK-based, ≥98.5% purity verified by HPLC, Royal Mail Tracked 24. Frequently studied alongside Ipamorelin 5MG and reconstituted using Bacteriostatic Water. View CJC-1295 No DAC 5MG
Important Notice: All content on this page is for laboratory research and educational purposes only. Not intended as medical advice or for human consumption.