BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide sequence derived from a protective protein found in human gastric juice. In laboratory models it is studied for its pleiotropic effects specifically its ability to modulate the VEGFR2 pathway and influence angiogenic signaling, mucosal integrity, and systemic tissue homeostasis.
Biological Mechanisms of Interest
Angiogenesis Modulation: BPC-157 is studied for its ability to upregulate Vascular Endothelial Growth Factor (VEGF), facilitating research into new blood vessel formation. Supporting literature: VEGF and angiogenic signaling PubMed
Nitric Oxide Synthesis: Observed to interact with NO pathways, influencing vascular tone and mucosal blood flow in laboratory models. Supporting literature: Nitric oxide and mucosal defense PubMed
Fibroblast Activation: Studied for its role in collagen synthesis and the FAK-paxillin signaling pathway, critical in extracellular matrix remodeling. Supporting literature: FAK signaling in tissue repair PubMed
Gastrointestinal Cytoprotection: As a gastric-derived peptide, it is a primary reagent for studying the brain-gut axis and mucosal defense mechanisms. Supporting literature: Brain-gut axis research PubMed
Technical Specifications
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Molecular Weight: 1419.5 Da Purity (HPLC): ≥99.0% Appearance: White Lyophilised Powder Solubility: Water, 1% Acetic Acid Storage: -20°C long-term
Research Applications
BPC-157 is actively utilised in musculoskeletal models studying tendon, ligament, muscle, and bone cellular responses. It is also a primary reagent in gastrointestinal integrity research and systemic inflammatory response models. Frequently studied alongside TB-500 for synergistic tissue repair research protocols.
Supporting literature: BPC-157 and tendon healing PubMed BPC-157 gastrointestinal research PubMed BPC-157 systemic effects PubMed
Our Recommended UK Supplier
BPC-157 is available from Peptronic Labs UK-based, ≥99.0% purity verified by HPLC, Royal Mail Tracked 24. View BPC-157 5MG
Important Notice: All content on this page is for laboratory research and educational purposes only. Not intended as medical advice or for human consumption.